| 12-lipoxygenase inhibitor | 23924 | A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. | DUKE |
| 5alpha-reductase inhibitor | 50781 | An EC 1.3.1.* (oxidoreductase acting on CH-CH group of donor, NAD(+) or NADP(+) as acceptor) inhibitor that interferes with the action of of 3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+)), EC 1.3.1.22, the enzyme which converts testosterone (CHEBI:17347) into the more potent androgen 5alpha-dihydrotestosterone. | DUKE |
| 5-hydroxyeicosatetraenoic-acid inhibitor | 35222 | A substance that diminishes the rate of a chemical reaction. | DUKE |
| 5-lipoxygenase inhibitor | 23924 | A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. | DUKE |
| 8-hydroxyeicosatetraenoic-acid inhibitor | 35222 | A substance that diminishes the rate of a chemical reaction. | DUKE |
| anti adenoma carcinogenic | 35610 | A substance that inhibits or prevents the proliferation of neoplasms. | DUKE |
| anti aflatoxin | 35222 | A substance that diminishes the rate of a chemical reaction. | DUKE |
| anti aggregant | | | DUKE |
| anti Alzheimeran | 52217 | Any substance introduced into a living organism with therapeutic or diagnostic purpose. | DUKE |
| anti amyloid-beta | | | DUKE |
| anti angiogenic | 48422 | An agent and endogenous substances that antagonize or inhibit the development of new blood vessels. | DUKE |
| anti arachidonate | 35222 | A substance that diminishes the rate of a chemical reaction. | DUKE |
| anti arthritic | 52217 | Any substance introduced into a living organism with therapeutic or diagnostic purpose. | DUKE |
| anti asthmatic | 49167 | A drug used to treat asthma. | DUKE |
| anti atherosclerotic | 38070 | A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres. | DUKE |
| anti bacterial | 33282 | A substance that kills or slows the growth of bacteria. | DUKE |
| anti bronchitic | 52217 | Any substance introduced into a living organism with therapeutic or diagnostic purpose. | DUKE |
| anti cancer | 35610 | A substance that inhibits or prevents the proliferation of neoplasms. | DUKE |
| anti carcinogenic | 35610 | A substance that inhibits or prevents the proliferation of neoplasms. | DUKE |
| anti cataract | 52217 | Any substance introduced into a living organism with therapeutic or diagnostic purpose. | DUKE |
| anti cholecystosic | | | DUKE |
| anti colitic | 52217 | Any substance introduced into a living organism with therapeutic or diagnostic purpose. | DUKE |
| anti collagenic | | | DUKE |
| anti Crohn's | 52217 | Any substance introduced into a living organism with therapeutic or diagnostic purpose. | DUKE |
| anti Epstein-Barr virus | 22587 | A substance that destroys or inhibits replication of viruses. | DUKE |
| anti eczemic | 52217 | Any substance introduced into a living organism with therapeutic or diagnostic purpose. | DUKE |
| anti edemic | | | DUKE |
| anti eicosanoid | 35222 | A substance that diminishes the rate of a chemical reaction. | DUKE |
| anti hepatotic | 62868 | Any compound that is able to prevent damage to the liver. | DUKE |
| anti HIV | 22587 | A substance that destroys or inhibits replication of viruses. | DUKE |
| anti inflammatory | 35472 | A substance that reduces or suppresses inflammation. | DUKE |
| anti integrase | 23924 | A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. | DUKE |
| anti ischemic | 52217 | Any substance introduced into a living organism with therapeutic or diagnostic purpose. | DUKE |
| anti leishmanic | 33281 | A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans. | DUKE |
| anti leukemic | 35610 | A substance that inhibits or prevents the proliferation of neoplasms. | DUKE |
| anti leukotriene | 35222 | A substance that diminishes the rate of a chemical reaction. | DUKE |
| anti lipoperoxidant | | | DUKE |
| anti lithic | | | DUKE |
| anti lymphomic | | | DUKE |
| anti melanomic | 35610 | A substance that inhibits or prevents the proliferation of neoplasms. | DUKE |
| anti metastatic | 35610 | A substance that inhibits or prevents the proliferation of neoplasms. | DUKE |
| anti mutagenic | | | DUKE |
| anti nitrosaminic | | | DUKE |
| antioxidant | 22586 | A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides. In European countries, E-numbers for permitted antioxidant food additives are from E 300 to E 324. | DUKE |
| anti papillomic | 22587 | A substance that destroys or inhibits replication of viruses. | DUKE |
| anti peroxidant | | | DUKE |
| anti proliferant | | | DUKE |
| anti prostaglandin | 49020 | A chemical substance which inhibits the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites. | DUKE |
| anti psoriatic | 52217 | Any substance introduced into a living organism with therapeutic or diagnostic purpose. | DUKE |
| anti spasmodic | 52217 | Any substance introduced into a living organism with therapeutic or diagnostic purpose. | DUKE |
| anti thrombotic | 50248 | Drug that acts on blood and blood-forming organs and those that affect the hemostatic system. | DUKE |
| anti thromboxane | 35222 | A substance that diminishes the rate of a chemical reaction. | DUKE |
| antitumor | 35610 | A substance that inhibits or prevents the proliferation of neoplasms. | DUKE |
| antitumor promoter | 35610 | A substance that inhibits or prevents the proliferation of neoplasms. | DUKE |
| anti ulcer | 49201 | One of various classes of drugs with different action mechanisms used to treat or ameliorate peptic ulcer or irritation of the gastrointestinal tract. | DUKE |
| anti viral | 22587 | A substance that destroys or inhibits replication of viruses. | DUKE |
| apoptotic | | | DUKE |
| cancer preventive | 35610 | A substance that inhibits or prevents the proliferation of neoplasms. | DUKE |
| cardiodepressant | 38070 | A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres. | DUKE |
| chelator | 38161 | A ligand with two or more separate binding sites that can bind to a single metallic central atom, forming a chelate. | DUKE |
| chemopreventive | 35610 | A substance that inhibits or prevents the proliferation of neoplasms. | DUKE |
| cholagogue | | | DUKE |
| choleretic | | | DUKE |
| cyclooxygenase-2 inhibitor | 50629 | A cyclooxygenase inhibitor that interferes with the action of cyclooxygenase 2. | DUKE |
| cyclooxygenase inhibitor | 35544 | A compound or agent that combines with cyclooxygenases (EC 1.14.99.1) and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of icosanoids, prostaglandins, and thromboxanes. | DUKE |
| cytochrome-P450 inhibitor | 50183 | An enzyme inhibitor that interferes with the activity of cytochrome P450 involved in catalysis of organic substances. | DUKE |
| cytotoxic | 52209 | A role played by the molecular entity or part thereof which causes the development of a pathological process. | DUKE |
| deodorant | | | DUKE |
| detoxicant | 50247 | Any protective agent counteracting or neutralizing the action of poisons. | DUKE |
| DNA-protective | | | DUKE |
| dye | 37958 | | DUKE |
| expectorant | 52217 | Any substance introduced into a living organism with therapeutic or diagnostic purpose. | DUKE |
| fibrinolytic | | | DUKE |
| fungicide | 24127 | A substance used to destroy fungal pests. | DUKE |
| glutathionigenic | | | DUKE |
| hepatoprotective | 62868 | Any compound that is able to prevent damage to the liver. | DUKE |
| hypocholesterolemic | | | DUKE |
| hypolipidemic | | | DUKE |
| hypotensive | | | DUKE |
| I-kappa-B-alpha-phosphorylation inhibitor | 35222 | A substance that diminishes the rate of a chemical reaction. | DUKE |
| IKB-kinase inhibitor | 23924 | A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. | DUKE |
| IKK inhibitor | 23924 | A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. | DUKE |
| immunostimulant | 50847 | A substance that augments, stimulates, activates, potentiates, or modulates the immune response at either the cellular or humoral level. A classical agent (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contains bacterial antigens. It could also be endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Its mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy is related to its antigen-specific immunoadjuvanticity. | DUKE |
| lipase inducer | | | DUKE |
| litholytic | | | DUKE |
| maltase-promoter | | | DUKE |
| multidrug resistance inhibitor | 35222 | A substance that diminishes the rate of a chemical reaction. | DUKE |
| metal chelator | 38161 | A ligand with two or more separate binding sites that can bind to a single metallic central atom, forming a chelate. | DUKE |
| matrix-metalloproteinase-9 inhibitor | 50664 | | DUKE |
| mucogenic | | | DUKE |
| nematicide | 25491 | A substance used to destroy pests of the phylum Nematoda (roundworms). | DUKE |
| neuroprotective | 63726 | Any compound that can be used for the treatment of neurodegenerative disorders. | DUKE |
| NF-kappa-B inhibitor | 35222 | A substance that diminishes the rate of a chemical reaction. | DUKE |
| nitric-oxide inhibitor | 35222 | A substance that diminishes the rate of a chemical reaction. | DUKE |
| nitric-oxide scavenger | | | DUKE |
| ornithine-decarboxylase inhibitor | 23924 | A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. | DUKE |
| pesticide | 25944 | Strictly, a substance intended to kill pests. In common usage, any substance used for controlling, preventing, or destroying animal, microbiological or plant pests. | DUKE |
| prostaglandin-E2 inhibitor | 35222 | A substance that diminishes the rate of a chemical reaction. | DUKE |
| phototoxic | | | DUKE |
| protein kinase C inhibitor | 37700 | An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of protein kinase C (EC 2.7.11.13). | DUKE |
| plasmodicide | | | DUKE |
| prostaglandin synthesis inhibitor | 35222 | A substance that diminishes the rate of a chemical reaction. | DUKE |
| protease inhibitor | 37670 | A compound which inhibits or antagonizes the biosynthesis or actions of proteases (endopeptidases). | DUKE |
| protein kinase inhibitor | 37699 | An EC 2.7.* (P-containing group transferase) inhibitor that interferes with the action of protein kinases. | DUKE |
| protein-tyrosine-kinase inhibitor | 23924 | A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. | DUKE |
| pulmonoprotective | | | DUKE |
| quinone-reductase inducer | | | DUKE |
| radioprotective | 35232 | Any pharmaceutical compound containing a radioisotope. | DUKE |
| sortase-A inhibitor | 23924 | A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. | DUKE |
| sucrase promoter | | | DUKE |
| TNF inhibitor | 35222 | A substance that diminishes the rate of a chemical reaction. | DUKE |
| topoisomerase-II inhibitor | 50750 | A topoisomerase inhibitor that inhibits DNA topoisomerase (ATP-hydrolysing), EC 5.99.1.3 (topoisomerase II), which catalyses ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. | DUKE |
| topoisomerase-I inhibitor | 50276 | A topoisomerase inhibitor that inhibits the bacterial enzymes of the DNA topoisomerases, Type I class (EC 5.99.1.2) that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. These bacterial enzymes reduce the topological stress in the DNA structure by relaxing negatively, but not positively, supercoiled DNA. | DUKE |
| ulcerogenic | | | DUKE |
| VEGF inhibitor | 35222 | A substance that diminishes the rate of a chemical reaction. | DUKE |
