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p-Coumaric acid (FDB002593)

Record Information
Version1.0
Creation date2010-04-08 22:05:26 UTC
Update date2020-09-17 15:31:12 UTC
Primary IDFDB002593
Secondary Accession NumbersNot Available
Chemical Information
FooDB Namep-Coumaric acid
Descriptiontrans-4-Coumaric acid or (e)-p-Coumaric acid, the trans-isomer of 4-coumaric acid, also known as 4-hydroxycinnamic acid, belongs to the class of organic compounds known as hydroxycinnamic acids. Hydroxycinnamic acids are compounds containing a cinnamic acid where the benzene ring is hydroxylated. 4-Hydroxycinnamic acid is a neutral compound. 4-Hydroxycinnamic acid exists in all living species, from bacteria to humans. 4-Hydroxycinnamic acid is found in highest concentrations in pepper (c. frutescens), pineapples, and sunflowers and in lower concentration in spinachs, kiwis, and sweet oranges. 4-Hydroxycinnamic acid has also been detected in wild rices, soursops, garden onions, hyssops, and avocado. This could make 4-hydroxycinnamic acid a potential biomarker for the consumption of these foods.
CAS Number7400-08-0
Structure
Thumb
MOLSDF3D-SDFPDBSMILESInChI View 3D Structure
Synonyms
Predicted Properties
PropertyValueSource
Water Solubility1.02 g/LALOGPS
logP1.74ALOGPS
logP1.83ChemAxon
logS-2.2ALOGPS
pKa (Strongest Acidic)4ChemAxon
pKa (Strongest Basic)-6ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area57.53 ŲChemAxon
Rotatable Bond Count2ChemAxon
Refractivity45.04 m³·mol⁻¹ChemAxon
Polarizability16.43 ųChemAxon
Number of Rings1ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Chemical FormulaC9H8O3
IUPAC name(2E)-3-(4-hydroxyphenyl)prop-2-enoic acid
InChI IdentifierInChI=1S/C9H8O3/c10-8-4-1-7(2-5-8)3-6-9(11)12/h1-6,10H,(H,11,12)/b6-3+
InChI KeyNGSWKAQJJWESNS-ZZXKWVIFSA-N
Isomeric SMILESOC(=O)\C=C\C1=CC=C(O)C=C1
Average Molecular Weight164.158
Monoisotopic Molecular Weight164.047344122
Classification
Description Belongs to the class of organic compounds known as hydroxycinnamic acids. Hydroxycinnamic acids are compounds containing an cinnamic acid where the benzene ring is hydroxylated.
KingdomOrganic compounds
Super ClassPhenylpropanoids and polyketides
ClassCinnamic acids and derivatives
Sub ClassHydroxycinnamic acids and derivatives
Direct ParentHydroxycinnamic acids
Alternative Parents
Substituents
  • Cinnamic acid
  • Coumaric acid
  • Coumaric acid or derivatives
  • Hydroxycinnamic acid
  • Styrene
  • 1-hydroxy-2-unsubstituted benzenoid
  • Phenol
  • Monocyclic benzene moiety
  • Benzenoid
  • Carboxylic acid derivative
  • Carboxylic acid
  • Monocarboxylic acid or derivatives
  • Organic oxide
  • Organic oxygen compound
  • Hydrocarbon derivative
  • Organooxygen compound
  • Carbonyl group
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External Descriptors
Ontology
Disposition

Route of exposure:

Source:

Biological location:

Role

Biological role:

Industrial application:

Foods
  • Cocoa and cocoa products

    • Grains:

    Nuts and legumes:

    Fruits and vegetables:

    Fats and oils:

    Beverages:

    Physico-Chemical Properties
    Physico-Chemical Properties - Experimental
    Spectra
    Spectra
    EI-MS/GC-MS
    TypeDescriptionSplash KeyView
    EI-MSMass Spectrum (Electron Ionization)splash10-03xr-6900000000-348f5c7c030570e0612f2015-03-01View Spectrum
    GC-MSp-Coumaric acid, non-derivatized, GC-MS Spectrumsplash10-014m-1981000000-e7648e85764a445a919cSpectrum
    GC-MSp-Coumaric acid, 2 TMS, GC-MS Spectrumsplash10-066v-3791000000-a5712bbe8401ef499b5aSpectrum
    GC-MSp-Coumaric acid, non-derivatized, GC-MS Spectrumsplash10-03di-8900000000-3bb023f80c1f54a16adcSpectrum
    GC-MSp-Coumaric acid, non-derivatized, GC-MS Spectrumsplash10-03xr-5900000000-a364c62c9122c0fbe6deSpectrum
    GC-MSp-Coumaric acid, non-derivatized, GC-MS Spectrumsplash10-014m-1981000000-e7648e85764a445a919cSpectrum
    GC-MSp-Coumaric acid, non-derivatized, GC-MS Spectrumsplash10-066v-3791000000-a5712bbe8401ef499b5aSpectrum
    GC-MSp-Coumaric acid, non-derivatized, GC-MS Spectrumsplash10-014m-1891000000-d8804981d3918cac534dSpectrum
    Predicted GC-MSp-Coumaric acid, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positivesplash10-014j-2900000000-7075c3e10f9df528109eSpectrum
    Predicted GC-MSp-Coumaric acid, 2 TMS, Predicted GC-MS Spectrum - 70eV, Positivesplash10-00xu-6390000000-3110f0f6eb462a38bb64Spectrum
    Predicted GC-MSp-Coumaric acid, non-derivatized, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
    MS/MS
    TypeDescriptionSplash KeyView
    MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negativesplash10-03di-0900000000-b58aab08954c973df04e2012-08-31View Spectrum
    MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negativesplash10-014i-0900000000-3ddb41572ba36a950e372012-08-31View Spectrum
    MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negativesplash10-014i-0900000000-ccac7f071084bc6600952012-08-31View Spectrum
    MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Negativesplash10-014i-3900000000-5dc8af06da0120779cff2012-08-31View Spectrum
    MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Negativesplash10-00kf-9500000000-9187edc4498ab4345e5a2012-08-31View Spectrum
    MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Negativesplash10-014i-0900000000-3d831c6acd9d3188de2f2012-08-31View Spectrum
    MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Negativesplash10-03di-0900000000-fbb6439b7d012045f3a82012-08-31View Spectrum
    MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) 30V, Negativesplash10-0002-0900000000-9e18d43a8d86f9b9e72b2012-08-31View Spectrum
    MS/MSLC-MS/MS Spectrum - DI-ESI-qTof , Negativesplash10-014i-0900000000-c45397049a7ba500b3322017-09-14View Spectrum
    MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , negativesplash10-03di-0900000000-b58aab08954c973df04e2017-09-14View Spectrum
    MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , negativesplash10-014i-0900000000-3ddb41572ba36a950e372017-09-14View Spectrum
    MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , negativesplash10-014i-0900000000-ccac7f071084bc6600952017-09-14View Spectrum
    MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , negativesplash10-014i-3900000000-5dc8af06da0120779cff2017-09-14View Spectrum
    MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , negativesplash10-00kf-9500000000-9187edc4498ab4345e5a2017-09-14View Spectrum
    MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , negativesplash10-014i-0900000000-3d831c6acd9d3188de2f2017-09-14View Spectrum
    MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , negativesplash10-03di-0900000000-fbb6439b7d012045f3a82017-09-14View Spectrum
    MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , negativesplash10-0002-0900000000-9e18d43a8d86f9b9e72b2017-09-14View Spectrum
    MS/MSLC-MS/MS Spectrum - 10V, Negativesplash10-03di-0900000000-c6491d0aaba639e3ae072021-09-20View Spectrum
    MS/MSLC-MS/MS Spectrum - 30V, Negativesplash10-0002-0900000000-9e18d43a8d86f9b9e72b2021-09-20View Spectrum
    MS/MSLC-MS/MS Spectrum - 35V, Negativesplash10-014i-0900000000-a183cce49af676c95d4e2021-09-20View Spectrum
    MS/MSLC-MS/MS Spectrum - 20V, Negativesplash10-014i-0900000000-1f13fa0e7a24be298cfb2021-09-20View Spectrum
    MS/MSLC-MS/MS Spectrum - 40V, Negativesplash10-00kf-9200000000-206402014014906dbe292021-09-20View Spectrum
    MS/MSLC-MS/MS Spectrum - EI-B (HITACHI M-52) , Positivesplash10-03di-8900000000-3bb023f80c1f54a16adc2012-08-31View Spectrum
    MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Positivesplash10-00kb-3900000000-1118928776a5a6e213db2012-08-31View Spectrum
    MS/MSLC-MS/MS Spectrum - DI-ESI-qTof , Positivesplash10-0002-0900000000-c5faa58d353ca1466c3c2017-09-14View Spectrum
    NMR
    TypeDescriptionView
    1D NMR1H NMR Spectrum (1D, DMSO, experimental)Spectrum
    1D NMR13C NMR Spectrum (1D, DMSO, experimental)Spectrum
    1D NMR13C NMR Spectrum (1D, 100 MHz, H2O, predicted)Spectrum
    1D NMR1H NMR Spectrum (1D, 100 MHz, H2O, predicted)Spectrum
    1D NMR13C NMR Spectrum (1D, 1000 MHz, H2O, predicted)Spectrum
    1D NMR1H NMR Spectrum (1D, 1000 MHz, H2O, predicted)Spectrum
    1D NMR13C NMR Spectrum (1D, 200 MHz, H2O, predicted)Spectrum
    1D NMR1H NMR Spectrum (1D, 200 MHz, H2O, predicted)Spectrum
    1D NMR13C NMR Spectrum (1D, 300 MHz, H2O, predicted)Spectrum
    1D NMR1H NMR Spectrum (1D, 300 MHz, H2O, predicted)Spectrum
    1D NMR13C NMR Spectrum (1D, 400 MHz, H2O, predicted)Spectrum
    1D NMR1H NMR Spectrum (1D, 400 MHz, H2O, predicted)Spectrum
    1D NMR13C NMR Spectrum (1D, 500 MHz, H2O, predicted)Spectrum
    1D NMR1H NMR Spectrum (1D, 500 MHz, H2O, predicted)Spectrum
    1D NMR13C NMR Spectrum (1D, 600 MHz, H2O, predicted)Spectrum
    1D NMR1H NMR Spectrum (1D, 600 MHz, H2O, predicted)Spectrum
    1D NMR13C NMR Spectrum (1D, 700 MHz, H2O, predicted)Spectrum
    1D NMR1H NMR Spectrum (1D, 700 MHz, H2O, predicted)Spectrum
    1D NMR13C NMR Spectrum (1D, 800 MHz, H2O, predicted)Spectrum
    1D NMR1H NMR Spectrum (1D, 800 MHz, H2O, predicted)Spectrum
    1D NMR13C NMR Spectrum (1D, 900 MHz, H2O, predicted)Spectrum
    1D NMR1H NMR Spectrum (1D, 900 MHz, H2O, predicted)Spectrum
    ChemSpider ID553148
    ChEMBL IDCHEMBL66879
    KEGG Compound IDC00811
    Pubchem Compound ID637542
    Pubchem Substance IDNot Available
    ChEBI IDNot Available
    Phenol-Explorer ID500
    DrugBank IDDB04066
    HMDB IDHMDB02035
    CRC / DFC (Dictionary of Food Compounds) IDCMP73-U:CMP73-U
    EAFUS IDNot Available
    Dr. Duke ID4-HYDROXYCINNAMIC-ACID|P-COUMARIC-ACID|P-HYDROXYCINNAMIC-ACID
    BIGG ID36077
    KNApSAcK IDC00000152
    HET IDHC4
    Food Biomarker OntologyNot Available
    VMH IDNot Available
    Flavornet IDNot Available
    GoodScent IDNot Available
    SuperScent IDNot Available
    Wikipedia IDCoumaric_acid
    Phenol-Explorer Metabolite ID454
    Duplicate IDSNot Available
    Old DFC IDSNot Available
    Associated Foods
    FoodContent Range AverageReference
    Processing...
    Biological Effects and Interactions
    Health Effects / Bioactivities
    EnzymesNot Available
    PathwaysNot Available
    MetabolismNot Available
    BiosynthesisNot Available
    Organoleptic Properties
    FlavoursNot Available
    Files
    MSDSshow
    References
    Synthesis ReferenceNot Available
    General ReferenceNot Available
    Content Reference— Rothwell JA, Pérez-Jiménez J, Neveu V, Medina-Ramon A, M'Hiri N, Garcia Lobato P, Manach C, Knox K, Eisner R, Wishart D, Scalbert A. (2013) Phenol-Explorer 3.0: a major update of the Phenol-Explorer database to incorporate data on the effects of food processing on polyphenol content. Database, 10.1093/database/bat070.
    — Duke, James. 'Dr. Duke's Phytochemical and Ethnobotanical Databases. United States Department of Agriculture.' Agricultural Research Service, Accessed April 27 (2004).
    — Shinbo, Y., et al. 'KNApSAcK: a comprehensive species-metabolite relationship database.' Plant Metabolomics. Springer Berlin Heidelberg, 2006. 165-181.