Ontological Term Details

Compound
FDB011872 (Arachidonic acid)
Term
Rofecoxib Action Pathway
Definition
like other nsaids, rofecoxib exerts its effects by inhibiting the synthesis of prostaglandins involved in pain, fever and inflammation. cox-2 catalyzes the conversion of arachidonic acid to prostaglandin g2 (pgg2) and pgg2 to prostaglandin h2 (pgh2).
Parent Term
Biochemical pathway
Parent Definition
A linked series of chemical reactions that occur in a defined order within or between organism cells, and lead to a known function or end product.
Other Compounds Mapped to 'Rofecoxib Action Pathway'
  • FDB001498 (Glutathione)
  • FDB012535 (L-Glutamic acid)
  • FDB031054 (NADP+)
  • FDB021909 (NADPH)
  • FDB003513 (Calcium)
  • FDB031004 (Mg2+)
  • FDB011872 (Arachidonic acid)
  • FDB022448 (Prostaglandin F2a)
  • FDB030979 (leukotriene-C4)
  • FDB031256 (Zn2+)

    • References